Diversification of arthropod Hox genes as a paradigm for the evolution of gene functions

Journal article

Averof, Dawes, Ferrier
Seminars in Cell and Developmental Biology, vol. 4, 1996, pp. 539-551

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APA Click to copy
Averof, Dawes, & Ferrier. (1996). Diversification of arthropod Hox genes as a paradigm for the evolution of gene functions. Seminars in Cell and Developmental Biology, 4, 539–551.

Chicago/Turabian Click to copy
Averof, Dawes, and Ferrier. “Diversification of Arthropod Hox Genes as a Paradigm for the Evolution of Gene Functions.” Seminars in Cell and Developmental Biology 4 (1996): 539–551.

MLA Click to copy
Averof, et al. “Diversification of Arthropod Hox Genes as a Paradigm for the Evolution of Gene Functions.” Seminars in Cell and Developmental Biology, vol. 4, 1996, pp. 539–51.

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@article{averof1996a,
  title = {Diversification of arthropod Hox genes as a paradigm for the evolution of gene functions},
  year = {1996},
  journal = {Seminars in Cell and Developmental Biology},
  pages = {539-551},
  volume = {4},
  author = {Averof and Dawes and Ferrier}
}

Abstract

Abstract Hox genes are highly conserved throughout the metazoans in both sequence, chromosomal arrangement, and function. Yet within the arthropods these genes have undergone considerable diversification. We examine ancestral and novel functions of arthropod Hox genes in an attempt to understand how these functions might evolve. We suggest that functional diversification of Hox genes begins with the acquisition of multiple distinctcis-regulatory elements responsible for different aspects of their gene expression. Gene duplication may serve to dissociate the functional-selective constraints associated with each of these regulatory elements and to allow divergence of the corresponding coding sequences.